Prophylaxis Against Covid-19: Analysis Of The Supply of Hydroxychloroquine and Ivermectin and Covid-19 Cases and Deaths




Hydroxychloroquine, Ivermectine, zithromycin, Mortality


Introduction: The prophylaxis of the COVID-19 diseases remains questionable, regarding ivermectin, hydroxychloroquine and azithromycin action. Objective: This is an interrupted time series ecological study where a temporal analysis of the consumption of medications in the pre-pandemic and pandemic periods in the São Lourenço do Oeste (SLO) city was performed. Material and methods: Data were collected monthly from January 2018 to March 2021 directly from pharmacies/drug stores for medications, and from April 2020 to March 2021 for COVID-19. The temporal analysis was performed using the Prain Winsten test. Associations between variables (drugs and COVID-19 data) were made by Spearman's correlation test. Results: The supply of ivermectin (coefficient, 7.71 p=0.005) and hydroxychloroquine increased (coefficient 26.84, p=0.021) in the pandemic; and azithromycin remained stable (p? 0.05). There was a positive correlation between new cases of COVID-19 and the supply of azithromycin, hydroxychloroquine and ivermectin (Spearman rho 0.857, 0.760 and 0.741 p<0.01, respectively) and a positive correlation between deaths with azithromycin (Spearman rho 0.690, p<0.01) and hydroxychloroquine (Spearman rho 0.617, p<0.05). Conclusions: According to our data, it is possible to infer that the increased supply of ivermectin, azithromycin or hydroxychloroquine was not able to reduce new cases or deaths by COVID-19, showing no effectiveness as prophylaxis of this disease.


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